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<\/a>Unlike most other cells in the body, neurons aren’t easily replaceable, which means that once they are lost, they cannot be recovered. The research was led by Manjithaya and the lead author of the scientific paper was S N Suresh, a PhD student at MBGU under Manjithaya. Aravinda Chavalmane and Shashank Rai also contributed to the research.<\/p>\n
What does 6-BIO do ?<\/strong><\/p>\n The molecule enables neuroprotection by autophagy. It augments the efficiency of the autophagy process by enhancing the basal level (the speed at which autophagy happens). “Simply put, it quickens the process of cells taking bad proteins, which have formed clumps, to the cleanroom,” Manjithaya said. The research found a popular protein called GSK-3 Beta (a glycogen synthase protein) doesn’t allow autophagy to take place at a fast pace in brains cells affected by Parkinson’s and other similar diseases. “Our molecule removes this and quickens the process of autophagy,” he said.<\/p>\n Tests and publishing<\/strong><\/p>\n The findings were published in Autophagy, a scientific journal edited by autophagy scientist Daniel J Klionsky.”Before sending them for peer review and publishing, we conducted tests in our lab, which were positive,” Manjithaya said. Following this, the team tested 6-Bio on a mouse whose brain cells behaved like those of patients with Parkinson’s, and the results were positive again.<\/p>\n They teamed up with James Chelliah and Abhik Paul from JNCASR’s Chelliah Lab and Phalguni Alladi, Vidyadhara DJ and Yarreiphang Haorei from Nimhans. Researchers said the discovery is not a magical cure for Parkinson’s but a breakthrough that can help find a therapeutic solution.<\/p>\n source: http:\/\/www.timesofindia.indiatimes.com \/ The Times of India \/ News> City News> Bangalore News \/ Chethan Kumar \/ TNN \/ May 23rd, 2017<\/p>\n","protected":false},"excerpt":{"rendered":" Bengaluru : City scientists\u00a0have found a new molecule that can enhance the efficiency of the autophagy\u00a0process in brain cells, that can significantly reduce their degeneration, which is the cause of diseases like Parkinson’s. The scientists have initiated procedures to patent the process of discovery and the molecule itself -a potential drug -both of which have … Continue reading Molecule discovery offers Ithope for Parkinson’s cure<\/span>
\nBad proteins which were found to cause neurodegenerative diseases were produced in yeast, which reacted in the same way as our brain cells. “The proteins began to form clumps and kill the yeast. We then introduced 6-Bio into the yeast and saw if it could prevent the death of the cells. It worked,” Manjithaya explained. A large part of Nobel laureate Ohsumi’s work on autophagy involved experiments on yeast.<\/p>\n